✔️ 2022-08-31 22:56:00 - Paris/France.
ushwankathelo: Ukubonakaliswa okugqithisileyo kokukhanya okuluhlaza okwesibhakabhaka okukhutshwa bubuchwepheshe bale mihla obunje ngeeselfowuni, oomabonwakude kunye nabahloli bekhompyuter, kuchaphazela umsebenzi wethu osisiseko weselula kwaye kunokukhawulezisa ukuguga, isifundo esitsha sibonisa.
Umthombo: Imida
Ukusetyenziswa kwesikrini ngokugqithiseleyo kuye kwadibaniswa nokutyeba kunye neengxaki zengqondo. Ngoku uphando olutsha luchonge ingxaki entsha - uphononongo kwiimpukane zeziqhamo lubonisa ukuba imisebenzi yethu esisiseko yeselula inokuchaphazeleka kukukhanya okuluhlaza okwesibhakabhaka okukhutshwa zezi zixhobo.
Ezi ziphumo zipapashwa kwi Imida yokuguga.
"Ukugqithisa ngokugqithiseleyo ukukhanya okuluhlaza okwesibhakabhaka ukusuka kwizixhobo zemihla ngemihla, ezifana nomabonwakude, iilaptops kunye neefowuni, kunokuba nemiphumo emibi kwiiseli ezininzi emzimbeni wethu, ukusuka kwesikhumba kunye neeseli ezinamafutha ukuya kwii-neurons," kusho uDkt. Jadwiga Giebultowicz, uprofesa. kwiSebe le-Integrative Biology kwiYunivesithi yaseOregon State kunye nombhali okhokelayo wolu phononongo.
"Singabokuqala ukubonisa ukuba amanqanaba e-metabolites athile - iikhemikhali eziyimfuneko ekusebenzeni ngokufanelekileyo kweeseli - zitshintshwa kwiimpukane zeziqhamo ezivezwe kukukhanya okuluhlaza okwesibhakabhaka. »
"Uphononongo lwethu lucebisa ukuba ukuphepha ukukhanya okuluhlaza okwesibhakabhaka okugqithisileyo kunokuba sisicwangciso esihle sokulwa nokuguga," ucebise uGiebultowicz.
Cima isibane
Abaphandi beYunivesithi yaseOregon State baye babonisa ngaphambili ukuba iimpukane zeziqhamo ezivezwe ekukhanyeni "zivula" imizila yemfuza ekhuselayo kuxinzelelo kwaye abo bagcinwe ebumnyameni obuhlala buhlala ixesha elide.
"Ukuqonda ukuba kutheni ukukhanya okuluhlaza okunamandla aphezulu kunoxanduva lokukhawulezisa ukuguga kwiimpukane zeziqhamo, sithelekisa amanqanaba e-metabolite kwiimpukane ezivezwe kukukhanya okuluhlaza kangangeeveki ezimbini nezo zigcinwe kubumnyama obupheleleyo.", ucacise uGiebultowicz.
Ukubonakaliswa kokukhanya okuluhlaza okwesibhakabhaka kubangele ukungafani okukhulu kumanqanaba e-metabolites abaphandi abalinganisa kwiiseli zeentloko zeempukane. Ngokukodwa, bafumanisa ukuba amanqanaba e-metabolite ye-succinate anyuswa, kodwa amanqanaba e-glutamate athotywa.
Abaphandi beYunivesithi yaseOregon State baye babonisa ngaphambili ukuba iimpukane zeziqhamo ezivezwe ekukhanyeni "zivula" imizila yemfuza ekhuselayo kuxinzelelo kwaye abo bagcinwe ebumnyameni obuhlala buhlala ixesha elide. Umfanekiso ukwidomeyini yoluntu
I-Succinate ibalulekile ekuveliseni amafutha afunekayo ukuze iseli nganye isebenze kwaye ikhule. Amanqanaba aphakanyisiweyo e-succinate emva kokuvezwa kokukhanya okuluhlaza okwesibhakabhaka anokufaniswa negesi esempompo kodwa ingangeni emotweni, ”utshilo uGiebultowicz. "Enye into ephazamisayo yokufunyaniswa kukuba iimolekyuli ezijongene nonxibelelwano phakathi kwee-neurons, ezifana ne-glutamate, zikumgangatho ophantsi emva kokuvezwa kokukhanya okuluhlaza. »
Ukukhawulezisa ukwaluphala
Utshintsho olubhalwe ngabaphandi lucebisa ukuba iiseli zisebenza kwinqanaba elingaphantsi, elinokukhokelela ekufeni kwabo kwangaphambi kwexesha, kwaye bachaze ngakumbi iziphumo zabo zangaphambili zokuba ukukhanya okuluhlaza okwesibhakabhaka kukhawulezisa ukuguga.
"Ii-LED ziye zaba lukhanyiso oluphambili lwezikrini zokubonisa ezifana neefowuni, iidesktops, kunye nomabonakude, kunye nokukhanya okukhoyo, ngoko ke abantu abakwimimandla ephakamileyo bavezwa ukukhanya okuluhlaza okwesibhakabhaka ngokukhanya kwe-LED ngexesha elininzi leeyure zabo zokuvuka. Iikhemikhali zomqondiso kwimpukane kunye neeseli zomntu ziyafana, ngoko ke kukho iziphumo ezingalunganga zokukhanya okuluhlaza ebantwini, utshilo uGiebultowicz.
Umsebenzi wexesha elizayo unethemba lokufunda iziphumo ngokuthe ngqo kwiiseli zomntu.
"Sisebenzise ukukhanya okuluhlaza okomeleleyo kwiimpukane - abantu bavezwe kukukhanya okuncinci, ngoko ke umonakalo weseli unokuba mkhulu kakhulu. Iziphumo zolu phononongo zibonisa ukuba uphando lwexesha elizayo olubandakanya iiseli zomntu luyafuneka ukuze kubonwe ubungakanani apho iiseli zomntu zinokubonisa utshintsho olufanayo kwi-metabolites ebandakanyekayo kwimveliso yamandla ekuphenduleni ukukhanya okuluhlaza okwesibhakabhaka okugqithisileyo. " , waqukumbela uGiebultowicz.
Malunga nezi ndaba zophando lokuguga
Umbhali: Mischa Dijkstra
Umthombo: Imida
Uqhagamshelwano: Mischa Dijkstra – Imida
Umfanekiso: Umfanekiso ukwidomeyini yoluntu
Bona kwakho
Uphando lokuqala: Ufikelelo lwasimahla.
"Ukukhanya okuluhlaza okungapheliyo kubangela ukuguga okukhawulezileyo kwi-Drosophila ngokuguqula amandla e-metabolism kunye namanqanaba e-neurotransmitter" nguJadwiga Maria Giebultowicz et al. Imida yokuguga
isishwankathelo
Ukukhanya okuluhlaza okungapheliyo kubangela ukuguga okukhawulezileyo kwi-Drosophila ngokuguqula amandla e-metabolism kunye namanqanaba e-neurotransmitter.
Ukukhanya okuluhlaza okwesibhakabhaka (BL) kuya kuxhaphaka ekukhanyeni okwenziweyo, ukuphakamisa inkxalabo malunga nobungozi obunokuthi bube yingozi kwimpilo yabantu. Ngapha koko, kukho ubungqina obubonisa ukuba ukuvezwa okubukhali kwi-BL kunokukhokelela kuxinzelelo lwe-oxidative kunye nokufa kweeseli ze-retinal ezikhethekileyo kwi-photoreception.
Kwelinye icala, izifundo zamva nje kwi I-Drosophila melanogaster Ubonise ukuba ukuchaneka okungapheliyo kwi-BL kubangela ukuguga okukhawulezileyo okubonakala njengokuncitshiswa kwexesha lokuphila kunye ne-neurodegeneration yobuchopho, nakwiempukane ezinamehlo acinyiweyo, ecebisa ukuba i-BL inokonakalisa iiseli kunye nezicubu ezingakhethekileyo ekuboneni ukukhanya.
Kwinqanaba le-physiological, ukuvezwa kwi-BL kuguqula umsebenzi we-mitochondrial kwiimpukane, kodwa i-metabolic underpinnings yale miphumo ayizange ifundwe. Apha, siye saphanda iziphumo ze-LB engapheliyo kwiindlela ze-metabolic kwiintloko ze amehlo alahlekileyo (ewe2) iimpukane eziguqukayo ukuze zigxile kwizicubu ze-retinal ezingaphezulu.
Siqhathanise iiprofayili ze-metabolomic kwiimpukane ezigcinwe kwi-10 okanye iintsuku ze-14 kwi-BL eqhubekayo okanye ubumnyama obungapheliyo, usebenzisa i-LC-MS kunye ne-GC-MS. Uhlalutyo lwedatha lubonakalise utshintsho olubalulekileyo kumanqanaba eemetabolites ezininzi ezibonisa ukuba iindlela ezibalulekileyo zeselula zichaphazeleka kwiimpukane ezivezwe kwi-BL.
Ngokukodwa, ukulungiswa kwakhona kwe-metabolic ephawulekayo kubonwa kwiintloko zeempukane ezigcinwe kwi-BL iintsuku ze-14, kubandakanywa amanqanaba aphezulu kakhulu e-succinate kodwa amanqanaba ancitshisiweyo e-pyruvate kunye ne-citrate, ebonisa utshintsho kwimveliso yamandla. Ezi mpukane zikwabonisa ukuqala kwe-neurodegeneration kunye nohlalutyo lwethu lufumene amanqanaba ancitshisiweyo ee-neurotransmitters ezininzi, kubandakanya i-glutamate kunye ne-gamma-aminobutyric acid (GABA), ebonisa ukuba i-BL iphazamisa i-homeostasis yobuchopho.
Zithathiwe kunye, ezi datha zibonelela ngemibono emitsha kwiindlela apho i-BL iphazamisana neendlela ezibalulekileyo zemetabolism ezigcinwe phakathi kweempukane kunye neeseli zomntu.
SOURCE: Uphonononga Iindaba
Ungalibazisi ukwabelana ngenqaku lethu kwiinethiwekhi zentlalo ukusinika ukomelela okuqinileyo. 🤟